METHOD OF CRYSTALLIZATION OF BICALUTAMIDE

摘要

The present invention provides a method of crystallization of bicalutamide comprising adding an acetone solution containing bicalutamide to water; crystals of bicalutamide wherein particle size distribution of the crystals is 1 to 10µm of D p10, 10 to 25 µm of D p50 and 25 to 100 µm of D p90, and the crystals are obtainable by the method described above; and crystals of bicalutamide, wherein particle size distribution of the crystals is 1 to 3 µm of D p10, 2 to 5 µm of D p50 and 5 to 15 µm of D p90.