Honey products with either a high or low arabinogalactan content, and the use of both to affect inflammation

摘要

A honey isolate containing type II arabinogalactan (AG), wherein the average molecular weight of the AG is 40,000 to 1,100,000 is disclosed, wherein the ratio of arabinose to galactose in the honey isolate may range from 0.1 to 2.0 parts arabinose to 1.0 parts galactose. Further disclosed is a method of producing a honey based immune-stimulatory composition by the steps of: (a) testing a series of honey batches for the presence of type II AG compounds; (b) selecting and blending together honeys based on the test results; and (c) isolating type II AG compounds from the honey and then processing the honey by steps selected from filtration, ultra-filtration, reverse osmosis, solvent extraction, precipitation, or combinations thereof and collecting a high molecular weight isolate from the processing step to form a honey blend with type II AG levels greater than 5 microgram/gram. The disclosure also relates to the use of a honey or a honey analogue based composition with type II AG compounds removed from the honey or a honey analogue in the manufacture of a topical formulation for treatment of a recalcitrant skin condition on a topical body area, a sensitive skin condition on a topical body area.