发明名称 |
Materials and methods relating to glycosylation of a therapeutic polypeptide |
摘要 |
Techniques to glycosylation are described, and more particularly to the production of glycosylation structures that are resistant to enzymatic degradation, thereby modulating one or more of their biological properties or those of therapeutic moieties incorporating them, and in particular to reacting activated carbohydrate substrates containing fluorine, such as 3-fluoro sialic acid compounds, with sugar acceptors to produce covalent conjugates of the sugar acceptor and one or more of the sialic acid compounds. |
申请公布号 |
EP2442831(A2) |
申请公布日期 |
2012.04.25 |
申请号 |
EP20100727485 |
申请日期 |
2010.06.16 |
申请人 |
THE UNIVERSITY OF BATH |
发明人 |
WATTS, ANDREW, GRAHAM;MACKENZIE, AMANDA, BARBARA;KANTNER, TERRENCE |
分类号 |
A61K47/48 |
主分类号 |
A61K47/48 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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