| 摘要 |
An isolated, synthetic or recombinant Ç-conotoxin peptide having the ability to inhibit neuronal amine transporter comprising the following sequence of amino acids:
Cys Cys Gly Tyr Lys Leu Cys Xaa5 Xaa6 Cys SEQ ID NO. 3
where Xaa5 and Xaa6 are independently absent or represent any amino acid residue except Cys;
or a sequence in which Gly, Tyr, Lys or Leu are subject to conservative amino acid substitution or side chain modification;
with the proviso that the peptide is not Ç-MrIA, Ç-MrIB, Mar2, CMrVIA, Bn1.5, Mr1.3 or Au1.4;
or a salt, ester, amide, prodrug or cyclised derivative thereof.
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