发明名称 |
Process for the fermentative production of heterologous proteins by means of Escherichia coli |
摘要 |
Producing a heterologous protein, comprises cultivating a Escherichia coli strain in a fermentation medium, and separating the heterologous protein from the medium, where the E. coli strain contains a gene encoding heterologous protein, the gene is functionally linked with a signal sequence encoding a signal peptide, the strain releases the heterologous protein into the fermentation medium and the E. coli strain exhibits an attenuated guanosine tetraphosphate (ppGpp)/guanosine pentaphosphate (pppGpp)-synthetase II activity (PSII activity). |
申请公布号 |
EP2204441(B1) |
申请公布日期 |
2011.07.13 |
申请号 |
EP20090178231 |
申请日期 |
2009.12.07 |
申请人 |
WACKER CHEMIE AG |
发明人 |
DASLER, TOBIAS, DR.;MITTERWEGER, SIMONE, DR.;WICH, GUENTER, DR. |
分类号 |
C12N1/00;C12N1/20 |
主分类号 |
C12N1/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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