发明名称 |
FULLY HUMAN ANTI-VEGF ANTIBODIES AND METHODS OF USING |
摘要 |
Vascular endothelial growth factor (VEGF) overexpression is associated with a variety of conditions involving aberrant angiogenesis. Disclosed herein are fully human antibodies that specifically bind human VEGF and inhibit VEGF binding to VEGF-R1 and VEGF-R2, and therefore inhibit VEGF signaling Based on their ability to inhibit VEGF signaling, the antibodies disclosed herein may be used to treat angiogenesis and conditions associated with angiogenesis both in vivo and in vitro.
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申请公布号 |
US2011076279(A1) |
申请公布日期 |
2011.03.31 |
申请号 |
US20070446438 |
申请日期 |
2007.10.22 |
申请人 |
SCHERING CORPORATION;XOMA TECHNOLOGY LTD. |
发明人 |
RAMACHANDRA SUMANT;BISHOP WALTER ROBERT;MASAT LINDA;HUANG CHAO BAI |
分类号 |
A61K39/395;A61P11/00;A61P11/06;A61P17/00;A61P17/06;A61P19/02;A61P27/02;A61P29/00;A61P35/00;C07H21/00;C07K16/22;C12N5/10;C12N15/63 |
主分类号 |
A61K39/395 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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