| 摘要 |
PROBLEM TO BE SOLVED: To provide a compound having an ability to bind to a sphingosine-1-phosphate (hereinafter referred to as S1P in some cases) receptor which is useful as a medicament and to provide a medicament containing the same as an active ingredient. SOLUTION: The compounds represented by formula (IA-1-1), salts thereof, solvates thereof or compounds in which carboxyl groups thereof are esterified. A compound having an ability to bind to an S1P receptor, (in particular EDG-6, preferably EDG-1 and EDG-6), for example the compounds represented by general formula (IA-1-1), salts thereof, solvates thereof or their prodrug have an ability to bind to the S1P receptor, (in particular EDG-6, preferably EDG-1 and EDG-6), and they are useful as preventives and/or remedies in rejection in transplantation, rejection of a transplanted organ, transplantation versus host disease, autoimmune diseases, allergic diseases and the like. COPYRIGHT: (C)2011,JPO&INPIT |
