发明名称 |
THE COMBINATION OF GROWTH HORMONE AND INSULIN-LIKE GROWTH FACTOR, FOR TREATING CONGESTIVE HEART FAILURE |
摘要 |
Methods of enhancing myocardial contractility and cardiac performance in a mammal with congestive heart failure are disclosed. In a first method a mammal with congestive heart failure is treated by administering to the mammal an effective amount of a combination of growth hormone (GH) and insulin-like growth factor (IGF-I). A second method comprises administering to the mammal an effective amount of a combination of GH and IGF-I in the presence of an ACE inhibitor. This method results in enhancement of myocardial contractility and cardiac performance above the level achieved with ACE inhibition alone. Preferably the mammal is a human.
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申请公布号 |
CA2185998(C) |
申请公布日期 |
2011.02.22 |
申请号 |
CA19952185998 |
申请日期 |
1995.03.30 |
申请人 |
GENENTECH, INC. |
发明人 |
CLARK, ROSS G.;JIN, HONGKUI;PAONI, NICHOLAS F.;YANG, RENHUI |
分类号 |
A61K38/28;A61K38/30;A61K31/40;A61K38/27;A61K45/00;A61P9/00;A61P9/04;A61P9/08;A61P9/10 |
主分类号 |
A61K38/28 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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