摘要 |
The invention relates to a method for analysing interactions of a nucleic acid with at least one polypeptide, comprising
(a) providing a reaction vessel with a composition comprising cross-linked complexes comprising at least one nucleic acid and at least one polypeptide;
(b) immobilizing at least part of the cross-linked complexes to the reaction vessel;
(c) at least partially reversing said cross-links in said immobilized complexes by performing a heat incubation step thereby at least partially releasing the nucleic acids from the complexes;
(d) analyzing the released nucleic acid. Also provided are specific reaction vessels and kits. |