| 摘要 |
<p><P>PROBLEM TO BE SOLVED: To provide sustained-release compositions wherein a water-soluble physiologically active peptide is substantially uniformly dispersed in microcapsules composed of a lactic acid polymer or a salt thereof. <P>SOLUTION: The sustained-release compositions comprises the physiologically active peptide in an amount of 15 to 35 (wt/wt)% to the total microcapsules and the lactic acid polymer with a weight-average molecular weight (Mw) of about 11,000 to about 27,000, and having a high content of the physiologically active substance, suppressing the initial excessive release within one day after the administration and a stable drug sustained-release over a long period of time, and the invention provides a method for producing the same. <P>COPYRIGHT: (C)2011,JPO&INPIT</p> |
