摘要 |
<p>The present invention is directed to novel water-soluble pharmaceutically acceptable, crystalline addition salts of (i) an amine containing one or more hydroxyl and/or carboxylic groups with (ii) amino nicotinic acid derivatives of formula (I) wherein Ra, Rb, Rc and Rd independently represent groups selected from hydrogen atoms, halogen atoms, C1-4 alkyl groups which may be optionally substituted by 1, 2 or 3 substituents selected from halogen atoms and hydroxy groups, and C1-4 alkoxy groups which may be optionally substituted by 1, 2 or 3 substituents selected from halogen atoms and hydroxy groups, and pharmaceutically acceptable solvates thereof.</p> |
申请人 |
ALMIRALL, S.A.;PEREZ GARCIA, JUAN, BAUTISTA;CARRERA CARRERA, FRANCESC;GARCIA MARTIN, DIGNA, JOSE;BOIX BERNARDINI, MARIA, CARMEN |
发明人 |
PEREZ GARCIA, JUAN, BAUTISTA;CARRERA CARRERA, FRANCESC;GARCIA MARTIN, DIGNA, JOSE;BOIX BERNARDINI, MARIA, CARMEN |