发明名称 |
CROSS-SPECIES-SPECIFIC PSCAXCD3, CD19XCD3, C-METXCD3, ENDOSIALINXCD3, EPCAMXC D3, IGF-1RXCD3 OR FAPALPHA XCD3 BISPECIFIC SINGLE CHAIN ANTIBODY |
摘要 |
The present invention relates to a bispecific single chain antibody molecule comprising a first binding domain capable of binding to an epitope of human and non-chimpanzee primate CD3 epsilon chain, wherein the epitope is part of an amino acid sequence comprised in the group consisting of SEQ ID NOs. 2, 4, 6, and 8, and a second binding domain capable of binding to an antigen selected from the group consisting of Prostate Stem Cell Antigen (PSCA), B-Lymphocyte antigen CD19 (CD19), hepatocyte growth factor receptor (C-MET), Endosialin, the EGF-like domain 1 of EpCAM, encoded by exon 2, Fibroblast activation protein alpha (FAP alpha) and Insulin-like growth factor I receptor (IGF-IR or IGF-1R). The invention also provides nucleic acids encoding said bispecific single chain antibody molecule as well as vectors and host cells and a process for its production. The invention further relates to pharmaceutical compositions comprising said bispecific single chain antibody molecule and medical uses of said bispecific single chain antibody molecule. |
申请公布号 |
WO2010037835(A3) |
申请公布日期 |
2010.07.15 |
申请号 |
WO2009EP62792 |
申请日期 |
2009.10.01 |
申请人 |
MICROMET AG;KUFER, PETER;RAUM, TOBIAS;KISCHEL, ROMAN;LUTTERBUESE, RALF;HOFFMANN, PATRICK;RAU, DORIS;KLINGER, MATTHIAS;MANGOLD, SUSANNE;BLUEMEL, CLAUDIA |
发明人 |
KUFER, PETER;RAUM, TOBIAS;KISCHEL, ROMAN;LUTTERBUESE, RALF;HOFFMANN, PATRICK;RAU, DORIS;KLINGER, MATTHIAS;MANGOLD, SUSANNE;BLUEMEL, CLAUDIA |
分类号 |
C07K16/28;C07K16/22;C07K16/30;C07K16/40 |
主分类号 |
C07K16/28 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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