CHEMISCH-ENZYMATISCHES VERFAHREN ZUR STEREOSELEKTIVEN HERSTELLUNG VON (R)-GAMMA-AMINO- BETA-HYDROXYBUTTERSÄURE ((R)-GABOB) UND (R)- CARNITIN

摘要

The present invention provides a chemoenzymatic process for the preparation of (R)-GABOB and (R)-carnitine employing lipase-mediated resolution of 3-hydroxy-4-tosyloxybutanenitrile as the key step. The drawing accompanying this specification represents the preparation of racemic 3-hydroxy-4-tosyloxybutanenitrile, its lipase-mediated kinetic resolution and its successful application in the preparation of (R)-GABOB and (R)-carnitine.