发明名称 |
USE OF SUBSTITUTED ACRYLOYL DISTAMYCIN DERIVATIVES IN THE TREATMENT OF TUMORS ASSOCIATED WITH HIGH LEVELS OF GLUTATHIONE |
摘要 |
Compounds which are .alpha.-halogenoacryloyl distamycin derivatives of formu la (I) wherein R1 is a bromine or chlorine atom; R2 is a distamycin or distamyc in- like framework as set forth in the specification; or a pharmaceutically acceptable salt thereof; are cytotoxic agents particularly effective in the treatment of tumors over expressing GSH/GSTs system and which are poorly responsive or even resistant to conventional antitumor therapies. |
申请公布号 |
CA2409664(C) |
申请公布日期 |
2010.01.12 |
申请号 |
CA20012409664 |
申请日期 |
2001.04.19 |
申请人 |
PHARMACIA ITALIA S.P.A. |
发明人 |
GERONI, MARIA CRISTINA ROSA;COZZI, PAOLO;BERIA, ITALO |
分类号 |
A61K31/395;C07D207/34;A61K31/40;A61K31/4025;A61K31/415;A61K31/4155;A61K31/4164;A61K31/4178;A61K31/4196;A61K31/506;A61K45/06;A61P1/00;A61P1/18;A61P11/00;A61P15/00;A61P35/00;A61P35/04 |
主分类号 |
A61K31/395 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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