Pharmaceutical formula and method for its production

摘要

Pharmaceutical formulation (Q) comprises a solid dispersion containing a polymer and an active agent, which is embedded in amorphous form into a polymer; and an external polymer, which is free of the solid dispersion, as a solution stabilizer; where: the polymer in the solid dispersion functions simultaneously as a solubility modifier and recrystallization inhibitor, and (Q) contains 3 wt.% to less than 20 wt.% of the external polymer, with respect to the total weight of the solid dispersion and external polymer. An independent claim is included for the preparation (Q) comprising melting and mixing the polymers and the active agent; cooling the obtained melt to the solid dispersion; mincing the solid dispersion; mixing the solid dispersion with the external polymer; and producing (Q) from the mixture. ACTIVITY : Antiseborrheic; Dermatological; Analgesic; Antiinflammatory; Anorectic; Antiarrhythmic; Antiasthmatic; Nootropic; Antidepressant; Antidiabetic; Antiemetic; Anticonvulsant; Hypotensive; Anticoagulant; Fungicide; Antiparkinsonian; Protozoacide; Antipsoriatic; Neuroleptic; Antirheumatic; Antialcoholic; Cytostatic; Diuretic; Immunosuppressive; Uropathic; Metabolic; Immunomodulator; Contraceptive; Cardiant; Vasotropic; Antilipemic; Gastrointestinal-Gen.; Antimalarial; Neuroprotective; Muscle relaxant; Osteopathic; Anti-HIV; Sedative; Tranquilizer; Virucide. MECHANISM OF ACTION : Calcium antagonist; Acetylcholinesterase inhibitor; Gyrase inhibitor; Phosphodiesterase inhibitor; Lipase inhibitor.