USE OF 1,4-BENZOTHIAZEPINE DERIVATIVES AS DRUGS FOR OVERCOMING RESISTANCE TO ANTICANCER DRUGS

摘要

The present invention relates to use of compounds represented by the following general formula [1] or salts or prodrugs thereof: <see formula I> [where R1 represents hydrogen atom or lower alkoxy group; RZ represents hydrogen atom, lower alkoxy group, optionally substituted phenyl group, <see formula> (where R3 represents acyl group); X represents -CO- or -CH2-; and n-represents 1 or 2], as drugs for overcoming a resistance to anticancer drugs or drugs for enhancing an effect of anticancer drugs. The compounds represented by the general formula [1] have not only a function of overcoming the resistance to various anticancer drugs but also a function of enhancing the effect of various anticancer drugs to anticancer-drug sensitive cells. Thus, these compounds have excellent effects on resistant cells and also on sensitive cells, and in particular effective in the treatment of a cancer having an acquired resistance to an anticancer drug.