| 摘要 |
<P>PROBLEM TO BE SOLVED: To provide a BiP gene-deficient mouse and more clearly determine the relationship between diseases and the functional estimation of BiP on individual level. <P>SOLUTION: The invention provides a knock-in non-human mammal having variation on BiP genome gene and free from the function of a localized mechanism of a KDEL receptor to the endoplasmic reticulum of BiP protein by the variation. The invention further provides a knock-in non-human mammal deficient in a BiP gene of a part encoding the carboxy-terminal lysine, aspartic acid, glutamic acid and leucine (KDEL) amino acid residue of the BiP protein. <P>COPYRIGHT: (C)2006,JPO&NCIPI |
