发明名称 |
Methods of diagnosing Alzheimer's disease and markers identified by set association |
摘要 |
<p>The present disclosure relates to genetic markers and methods of diagnosing and screening for late-onset Alzheimer's disease (LOAD). As such, the disclosure encompasses a whole-genome association analysis of single nucleotide polymorphisms (SNPs) of which a number are located within the GRB2-associated binding protein 2 (GAB2) gene as well as other markers associated with other genes. The disclosure identifies two novel haplotypes within the GAB2 gene, i.e., a LOAD risk-enhancing and a LOAD risk-decreasing haplotype. These haplotypes modify LOAD risk differentially in combination with APOE alleles. Further encompassed are therapeutic methods and agents of decreasing the deterioration of cells associated with LOAD.</p> |
申请公布号 |
AU2008242625(A1) |
申请公布日期 |
2008.10.30 |
申请号 |
AU20080242625 |
申请日期 |
2008.04.21 |
申请人 |
KRONOS SCIENCE LABORATORY;TRANSLATIONAL GENOMICS RESEARCH INSTITUTE |
发明人 |
CHRISTOPHER B. HEWARD;ANDREAS PAPASSOTIROPOULOS;ERIC M. REIMAN;JENNIFER WEBSTER;DIETRICH A. STEPHAN |
分类号 |
C12Q1/68;G01N31/00 |
主分类号 |
C12Q1/68 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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