THE IL-1 GENE CLUSTER, INSULIN RESISTANCE AND CORONARY ARTERY DISEASE ASSOCIATED POLYMORPHISMS AND HAPLOTYPES AND METHODS OF USING SAME

摘要

The invention provides methods and compositions relating to identification and use of genetic information from the IL-I gene cluster - including the structure and organization of novel IL-1-like genes found within the IL-I locus as well as polymorphisms and associated haplotypes within these genes. The invention thereby expands the repertoire of useful genetic information available from the IL-I locus - which contains the previously-identified IL-la, IL-lß and EL- IRN genes, for predicting IL-I associated phenotypes (e.g. increased or decreased risks of insulin resistance associated pathologies) and for treating EL-I haplotype associated insulin resistance associated pathologies.