COMPUESTOS DERIVADOS DE PIRIMIDILCICLOPENTANOS HIDROXILADOS Y METOXILADOS; PROCEDIMIENTO DE PREPARACION; COMPOSICION FARMACEUTICA; Y USO DEL COMPUESTO EN EL TRATAMIENTO DE UNA ENFERMEDAD INFLAMATORIA, HIPERPROLIFERANTE, CARDIOVASCULAR, NEURODEGENERAT
摘要
The present invention provides compounds, including resolved enantiomers, resolved diastereomers, solvates and pharmaceutically acceptable salts thereof, comprising the Formula I : Also provided are methods of using the compounds of this invention as AKT protein kinase inhibitors and for the treatment of hyperproliferative diseases such as cancer. Further provided are method of synthesis of these compounds and intermediates in the synthesis process.
申请公布号
CL2007001993(A1)
申请公布日期
2008.06.20
申请号
CL20070001993
申请日期
2007.07.06
申请人
ARRAY BIOPHARMA, INC., GENENTECH, INC.
发明人
MITCHELL, IAN S., BLAKE, JAMES, XU, RUI, KALLAN, NICHOLAS C., XIAO, DENGMING, SPENCER, KEITH L., BENCSIK, JOSEF.