| 摘要 |
<p>An affinity-conjugated antigen system (ACAS) comprising one or more antig ens conjugated via a plurality of affinity moieties to a papaya mosaic virus (PapMV) or virus-like particle (VLP) derived from the coat protein of PapMV is provided. The affinity moieties are molecules or compounds that are capa ble of specifically binding to the antigen(s) of interest and which can be a ttached, for example by chemical or genetic means, to the coat protein of th e PapMV or PapMV VLP. The ACAS can optionally further comprise one or more a dditional antigens, which may be the same as, or different to, the conjugate d antigen(s) comprised by the ACAS. Also provided are immunogenic compositio ns, including vaccines, comprising an ACAS. The immunogenic compositions are useful in the treatment, including prevention, of various diseases and diso rders for which a humoral and/or cellular response in the animal is required .</p> |
