发明名称 |
MOUSE LAMBDA LIGHT CHAIN LOCUS |
摘要 |
The present invention relates in one aspect to a method of making a knock-out mouse having its lambda light chain locus C2-C4-C3-C1 deleted using LoxP constructs as the targeting constructs and ubiquitous Cre-expresser mice. Also provided is a method of making a double knock-out mouse that has both the lambda light chain and the kappa light chain loci deleted. A heavy chain only antibody produced in a mouse in which at least the lambda light chain locus is functionally silenced is a further aspect of the invention. |
申请公布号 |
EP1399559(B1) |
申请公布日期 |
2008.04.30 |
申请号 |
EP20020732970 |
申请日期 |
2002.06.21 |
申请人 |
THE BABRAHAM INSTITUTE |
发明人 |
BRUEGGEMANN, MARIANNE;ZOU, XIANGANG |
分类号 |
C12N15/13;A01K67/027;C07K16/00 |
主分类号 |
C12N15/13 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|