METHODS OF MODULATING CELLULAR ACTIVITY AND COMPOSITIONS THEREFOR

摘要

The specification discloses methods for modulating hematopoietic cell number and/or activity and especially hematopoietic stem cell functional activity. The specification further provides methods of screening epigenetic modulators and other agents that modulate the level and/or activity of polycomb proteins such as Suz12. Genetically modified non-human animals and genetically modified cells that are Suz12 deficient are also contemplated together with their use and the use of animal models of hematopoietic and particularly platelet deficiency to develop epigenetic modifier agents.