CONTROLLED RELEASE SOLID PREPARATION

摘要

Disclosed is a controlled release solid preparation which is excellent in stability of an active ingredient, can exert a pharmacological effect steadily and rapidly after administration and can retain the pharmacological effect for a prolonged period of time. The controlled release solid preparation comprises a combination of a rapid release part and a controlled release part, wherein the rapid release part comprises an antacid (1), a compound unstable under acidic conditions (2) and a basic substance and the controlled release part comprises a coating film comprising a compound unstable under acidic conditions (3) and a basic substance and capable of being dissolved at a pH value equal to or higher than 6.5.