| 摘要 |
The present invention provides a system for delivering a therapeutic agent into tissue in combination with an implant device ( 2 ). Preferably the therapeutic substance is contained within a pellet form ( 14 ) that is deliverable into the interior of the device ( 2 ) after it has been implanted. In a preferred embodiment the implant device ( 2 ) comprises a flexible coiled spring body, the coils ( 4 ) of which have the proper diameter and spacing to contain the pellet ( 14 ) within the interior of the device ( 2 ) to contact the therapeutic agent. In treatment of ischemic tissue such as that of the myocardium of the heart, the mechanical irritation of the tissue caused by the implanted device ( 2 ) can help to provide an angiogenic effect. Additionally, the cavity ( 18 ) provided by the interior of the device ( 2 ) permits blood to pool around the pellet ( 14 ) and mix with the therapeutic agent. Several delivery systems have provided for delivering the implant and pellet ( 14 ) sequentially or simultaneously.
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