摘要 |
<p>In one aspect the invention provides a bioreactor system (51) for the production of tissue prostheses, the system comprising: a bioreactor (3) having an input port (15) and an output port (19), a culture medium reservoir (5) having an input port (23) and an output port (11), a first conduit (9) coupled between the bioreactor input port and the reservoir output port, a second conduit (17) coupled between the bioreactor output port and the reservoir input port, pump means (7) operable to pump fluid into and draw fluid out of a pumping chamber defined in the bioreactor to generate a pulsatile flow of culture medium through the reservoir and bioreactor via said first and second conduits, one or more flow meters (13, 21) operable to generate flow rate signals representative of the rate of culture medium flow through one or both of said first and second conduits, and control means (55) arranged to receive said flow rate signals from said one or more flow meters and to control the pump means in response to said received flow rate signals to provide a desired rate of culture medium flow.</p> |
申请人 |
UNIVERSITAET ZUERICH;HOERSTRUP, SIMON, P.;ZUEND, GREGOR |
发明人 |
HOERSTRUP, SIMON, P.;ZUEND, GREGOR |