发明名称 |
SLC1A1 MARKER FOR ANXIETY DISORDER |
摘要 |
The present invention provides methods for diagnosing or identifying susceptibility of a subject to an anxiety or mood disorder. One method involves testing a sample obtained from the subject for the presence of a polymorphism in Intron 10 of the SLC1 A1 gene. The presence of allele G or allele A of the A/G polymorphism rs301434 indicates that the patient is susceptible to an anxiety disorder. An alternate method involves testing a sample obtained from the subject for the presence of a polymorphism in the 3 ' untranslated region of the SLC1A1 gene. The presence of allele C of C/G polymorphism rs3087879 indicates that the patient is susceptible to an anxiety disorder. Furthermore, a method is provided that involves testing a sample obtained from the subject for the presence of a haplotype in the SLC1A1 gene, wherein the combined presence allele G of the A/G polymorphism rs301434 and allele C of C/G polymorphism rs3087879 indicates that the patient is susceptible to a mood disorder. |
申请公布号 |
CA2528222(A1) |
申请公布日期 |
2007.04.30 |
申请号 |
CA20052528222 |
申请日期 |
2005.12.23 |
申请人 |
CENTRE FOR ADDICTION AND MENTAL HEALTH |
发明人 |
KENNEDY, JAMES LOWERY;RICHTER, MARGARET A.;ARNOLD, PAUL DANIEL |
分类号 |
C12Q1/68;A61K38/17;C12N15/12 |
主分类号 |
C12Q1/68 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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