发明名称 |
INFLUENZA IMMUNOGEN AND VACCINE. |
摘要 |
<p>A chimeric, carboxy-terminal truncated hepatitis B virus nucleocapsid (HBc) protein is disclosed that contains an immunogen for inducing the production of antibodies to the influenza M2 protein. An immunogenic influenza sequence in two to four copies is preferably expressed at or near the N-terminus or in the HBc immunogenic loop sequence. The HBc chimer preferably contains an influenza-specific T cell epitope and is preferably engineered for both enhanced stability of self-assembled particles and enhanced yield of those chimeric particles. Methods of making and using the chimers are also disclosed.</p> |
申请公布号 |
MXPA06006185(A) |
申请公布日期 |
2007.03.15 |
申请号 |
MX2006PA06185 |
申请日期 |
2004.12.09 |
申请人 |
APOVIA, INC. |
发明人 |
WALTER FIERS;ASHLEY BIRKETT |
分类号 |
A61K;A61K39/00;A61K39/015;A61K39/145;A61K39/29;A61K39/295;A61K39/385;C07K14/02;C07K14/11;C07K17/00;C12N7/04 |
主分类号 |
A61K |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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