Methods of constructing biodiverse gene fragment libraries and biological modulators isolated therefrom

摘要

The present invention provides a gene fragment expression library comprising a plurality of different nucleotide sequences derived from biodiverse organisms and a method for identifying a modulator or mediator of a biological activity, which activity includes antigenicity and/or immunogenicity, said method comprising the steps of: (i) producing a gene fragment expression library derived from defined nucleotide sequence fragments; and (ii) assaying the expression library for at least an amino acid sequence derived from step (i) for a biological activity wherein that act