RECOMBINANT HERPES SIMPLEX VIRUS AND USES THEREFOR

摘要

Provided is a replication-deficient HSV encoding a heterologous antigen, and a vaccine comprising the HSV. The vaccine may be directed to viruses, intracellular bacteria or tumours. Also provided is an anticancer vaccine comprising replication-deficient HSV encoding an angiogenesis inhibitor, a cytokine and a suicide gene. A challenge model for screening candidate antigens is also provided, as is an UL13 mutant HSV vector. Further provided are HSV vectors for expression of Hex A and NTFs, and methods comprising said HSV.