| 摘要 |
A pharmaceutical carrier or excipient systems and oral pharmaceutical formulations comprising as an active ingredient raloxifene, amoxifen, droloxifene, arzoxifene, or CP 336156, or analogs thereof, or a compound of formulae (I) or (II) or a pharmaceutically acceptable salt thereof; and excipients chosen from pharmaceutical fillers, glidants, lubricants, wetting agents and antioxidants is disclosed, wherein: Z is a moiety selected from the group of formulae (a, b or c); R1 is selected from H, OH or the C1-C12 esters alkyl ethers thereof, benzyloxy, or halogen; or C1-C4 halogenated ethers; R2, R3, R4, R5, and R6 are H, OH or C1-C12 esters or alkyl ethers thereof, halogens, or C1-C4 halogenated ethers, cyano, C1-C6 alkyl, or CF3, with the proviso that, when R1 is H, R2 is not OH; Y is the moiety of formula (d), wherein R7 and R8 are alkyl or concatenated together to form an optionally substituted, nitrogen-containing ring.
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