USE OF THE LIPOXIN RECEPTOR, FPRL1, AS A TOOL FOR IDENTIFYING COMPOUNDS EFFECTIVE IN THE TREATMENT OF PAIN AND INFLAMMATION
摘要
Disclosed herein are compounds that selectively activate the FPRL1 receptor. Further disclosed are methods of alleviating inflammatory responses by regulating key steps in leukocyte trafficking and preventing neutrophil-mediated tissue damage by administering to a subject a therapeutically effective amount of the compounds disclosed herein. In addition, methods of modulating, or specifically agonizing, the FPRL1 receptor by administering an effective amount of the compounds disclosed herein are provided.
申请公布号
WO2005047899(A2)
申请公布日期
2005.05.26
申请号
WO2004US36952
申请日期
2004.11.04
申请人
ACADIA PHARMACEUTICALS INC.;NASH, NORMAN;SCULLY, AUDRA, L.;GARDELL, LUIS;OLSSON, ROGER;GUSTAFSSON, MAGNUS
发明人
NASH, NORMAN;SCULLY, AUDRA, L.;GARDELL, LUIS;OLSSON, ROGER;GUSTAFSSON, MAGNUS