摘要 |
The present invention concerns a process for the preparation of a 2,5-disubstituted pyridine of the formula (I) <CHEM> which comprises the steps of a) reacting a compound of the formula (II) R<1>-CH=CH-R<2> with an acrylic compound of the formula (III) <CHEM> to form a compound of the formula (IV) <CHEM> and b) reacting the compound of formula (IV) under water free conditions with a hydrogen halide in which formulae R<1> signifies lower alkyl, R<2> signifies di-(lower alkyl)amino or a 5- or 6- membered -N-heterocyclyl group having the free valence bond at the nitrogen atom, and X signifies halogen. |