| 发明名称 |
Oncolytic adenovirus |
| 摘要 |
Viral vectors and methods of making such vectors are described that preferentially kill neoplastic but not normal cells, the preferred vector being an adenovirus that has the endogenous promoters in the E1A and/or E4 regions substituted with a tumor specific promoter which is preferably E2F responsive.
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| 申请公布号 |
US2004151696(A1) |
申请公布日期 |
2004.08.05 |
| 申请号 |
US20020303598 |
申请日期 |
2002.11.25 |
| 申请人 |
JOHNSON LEISA;FATTAEY ALI;HERMISTON TERRY;SHEN YUQIAO;LAQUERRE SYLVIE |
发明人 |
JOHNSON LEISA;FATTAEY ALI;HERMISTON TERRY;SHEN YUQIAO;LAQUERRE SYLVIE |
| 分类号 |
A61K35/76;C12N15/861;(IPC1-7):A61K48/00 |
主分类号 |
A61K35/76 |
| 代理机构 |
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