3-PYRROLYL UREA DERIVATIVES AND THEIR USE AS ANTIVIRAL AGENTS

摘要

The invention relates to substituted pyrroles of formula (I), in which: R1 represents -OR8 or -NR9R10; R2 represents hydrogen, C1-C6 alkyl or aryl, whereby R2 as an alkyl can be substituted with 0, 1, 2 or 3 substituents R2- 1 independently of one another, selected from the group comprising halogen, hydroxy, C1-C6 alkoxy, hydroxycarbonyl, C1-C6 alkoxycarbonyl, C1- C6alkylcarbonyloxy, amino, C1-C6 alkylamino, aminocarbonyl, C1-C6 alkylaminocarbonyl, C3-C8 cycloalkyl, a 5- to 10-membered heterocyclyl, C6-C 10 aryl, phenoxy and a 5- to 10-membered heteroaryl and whereby R2 as an aryl c an be substituted with 0, 1, 2 or 3 substituents R2-2 independently of one another, selected from the group comprising halogen, hydroxy, nitro, cyano, trifluoromethyl, trifluoromethoxy, C1-C6 alkyl, C1-C6 alkoxy, hydroxycarbony l, C1-C6 alkoxycarbonyl, amino, C1-C6 alkylamino, aminocarbonyl, C1-C6 alkylaminocarbonyl, C3-C8 cycloalkyl, a 5- to 10-membered heterocyclyl, C6- C10 aryl and a 5- to 10-membered heteroaryl; R3 and R4 independently of one another represent hydrogen or C1-C6 alkyl; R5 and R6 independently of one another represent hydrogen or C1-C6 alkyl; and R7 represents a 3- to 12- membered carbocyclyl, whereby the carbocyclyl can be substituted with 0, 1, 2, 3, 4 or 5 substituents independently of one another, selected from the group comprising halogen, hydroxy, C1-C6 alkyl and C1-C6 alkoxy. The invention als o relates to a method for producing said pyrroles, to their use for the treatment and/or prophylaxis of diseases, in addition to their use for producing medicaments for the treatment and/or prophylaxis of diseases, notably to their use as antiviral agents, in particular against cytomegaloviruses.