ESTROGEN RECEPTOR INTERACTION WITH A TRANSCRIPTION FACTOR

摘要

The invention provides a method to measure a direct interaction between an estrogen receptor and a transactivation protein in an in vitro system by providing for a detection parameter proportionally related to the degree of the interaction, whereby the transactivation protein is c-Rel. In an embodiment of the invention a yeast two-hybrid assay for the measurement is provided. Also is provided a method to influence the direct interaction between an estrogen receptor (ER) and c-Rel in a system, by addition to the system of a compound, which influences the direct interaction between an estrogen receptor (ER) and c-Rel.