| 摘要 |
The present invention concerns compositions and methods related to isolating and using human GHB receptors (hGHB receptor), as well as agents that modify the physical, chemical, and biological properties or activities of hGHB receptors. Isolation of an hGHB receptor and the polynucleotide(s) encoding an hGHB receptor allow the use of biotechnological approaches to screen for and identify compounds that affect or modulate receptor activity. Compounds identified will typically have advantageous properties such as stimulation, enhancement, or induction of SWS; biologic, chemical, and/or storage stability; less toxicity; higher potency; higher selectivity; fewer side effects and/or other beneficial physical, biological and pharmacologic characteristics. |
