摘要 |
The present invention disclosed compositions comprising a stabilized Exendin-4 (1-39) and related compounds. The invention describes stabilized Exendin-4 agonists that include at least one modified amino acid residue particularly at positions Gln 13, Met14, Trp25, or Asn28 of the Exendin-4 (1-39) molecule. Disclosed are preferred modifications of deaminated, hydrolyzed, oxidized, or isomerized reaction products of the specified amino acid residues corresponding to the same positions in the Exendin-4 molecule. The invention also relates to methods of making and using the stabilized Exendin compounds, such as for the treatment of diabetes. |
申请人 |
ZEALAND PHARMA A/S;EBBEHOEJ, KIRSTEN;JEPSEN, TRINE;KNUDSEN, CARSTEN BOYE;LARSEN, BJARNE, DUE;KNOTT, DAVID |
发明人 |
EBBEHOEJ, KIRSTEN;JEPSEN, TRINE;KNUDSEN, CARSTEN BOYE;LARSEN, BJARNE, DUE;KNOTT, DAVID |