发明名称 |
Methods and compositions for transforming dendritic cells and activating T cells |
摘要 |
Recombinant dendritic cells are made by transforming a stem cell and differentiating the stem cell into a dendritic cell. The resulting dendritic cell is an antigen presenting cell which activates T cells against MHC class I-antigen targets. Kits, assays and therapeutics are based upon the activation of T cells by the recombinant dendritic cell. Cancer, viral infections and parasitic infections are all ameliorated by the recombinant dendritic cells, or corresponding activated T cells. Therapeutic compositions and pharmaceutical compositions are provided.
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申请公布号 |
US6734014(B1) |
申请公布日期 |
2004.05.11 |
申请号 |
US19990117764 |
申请日期 |
1999.01.07 |
申请人 |
THE UNITED STATES OF AMERICA AS REPRESENTED BY THE DEPARTMENT OF HEALTH AND HUMAN SERVICES |
发明人 |
HWU PATRICK;REEVES MARK;ROSENBERG STEVEN A. |
分类号 |
C12N5/02;C12N5/0784;(IPC1-7):A61K48/00;C12N15/63;C12N15/85 |
主分类号 |
C12N5/02 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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