发明名称 |
Anti-invasive and anti-angiogenic compositions |
摘要 |
A peptide compound having the sequence Lys-Pro-Ser-Ser-Pro-Pro-Glu-Glu [SEQ ID NO:2] or a substitution variant, addition variant or other chemical derivative thereof inhibits cell invasion, endothelial tube formation or angiogenesis in vitro. A number of substitution variants and addition variants of this peptide, preferably capped at the N- and C-termini, as well as peptidomimetic derivatives, are useful for treating diseases and conditions mediated by undesired and uncontrolled cell invasion and/or angiogenesis. Pharmaceutical compositions comprising the above peptides and derivatives are administered to subjects in need of such treatment in a dosage sufficient to inhibit invasion and/or angiogenesis . The disclosed compositions and methods are particularly useful for suppressing the growth and metastasis of tumors.
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申请公布号 |
US6696416(B1) |
申请公布日期 |
2004.02.24 |
申请号 |
US19990437136 |
申请日期 |
1999.11.10 |
申请人 |
ANGSTROM PHARMACEUTICALS, INC. |
发明人 |
MAZAR ANDREW P.;JONES TERENCE R. |
分类号 |
A61K38/00;A61P35/00;C12N9/72;(IPC1-7):A61K38/00 |
主分类号 |
A61K38/00 |
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