发明名称 |
PROCESS FOR THE PREPARATION OF 5-SUBSTITUTED ISOBENZOFURANS |
摘要 |
There is described a process for the preparation of citalopram and of its pharmaceutically acceptable salts, which comprises treating a 1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl)-1,3-dihydro-5-isobenzofurancarbaldoxime, O-substituted preferably with a diphenylmethyl or triphenylmethyl group, with formic-acetic anhydride. Furthermore, the total synthesis of citalopram, as free base or in form of its pharmaceutically acceptable salt, starting from 5-formylphthalide is described.
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申请公布号 |
WO03011846(B1) |
申请公布日期 |
2003.12.24 |
申请号 |
WO2002EP08550 |
申请日期 |
2002.07.29 |
申请人 |
INFOSINT SA;DALL'ASTA, LEONE;COTTICELLI, GIOVANNI |
发明人 |
DALL'ASTA, LEONE;COTTICELLI, GIOVANNI |
分类号 |
C07D307/87;A61K31/343;A61P25/24;C07B57/00;C07C249/12;C07C251/48;C07D307/88;(IPC1-7):C07D307/80;C07C251/42 |
主分类号 |
C07D307/87 |
代理机构 |
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地址 |
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