发明名称 |
Chemokine receptor binding heterocyclic compounds with enhanced efficacy |
摘要 |
The invention relates to heterocyclic compounds consisting of a core nitrogen atom surrounded by three pendant groups, wherein two of the three pendant groups are preferably benzimidazolyl methyl and tetrahydroquinolyl, and the third pendant group contains N and optionally contains additional rings. The compounds bind to chemokine receptors, including CXCR4 and CCR5, and demonstrate protective effects against infection of target cells by a human immunodeficiency virus (HIV).
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申请公布号 |
US2003220341(A1) |
申请公布日期 |
2003.11.27 |
申请号 |
US20020329329 |
申请日期 |
2002.12.23 |
申请人 |
BRIDGER GARY;SKERLJ RENATO;KALLER AI;HARWIG CURTIS;BOGUCKI DAVID;WILSON TREVOR R.;CRAWFORD JASON;MCEACHERN ERNEST J.;ATSMA BEM;NAN SIQIAO;ZHOU YUANXI;SCHOLS DOMINIQUE;SMITH CHRISTOPHER DENNIS;DI FLURI MARIA ROSARIA |
发明人 |
BRIDGER GARY;SKERLJ RENATO;KALLER AI;HARWIG CURTIS;BOGUCKI DAVID;WILSON TREVOR R.;CRAWFORD JASON;MCEACHERN ERNEST J.;ATSMA BEM;NAN SIQIAO;ZHOU YUANXI;SCHOLS DOMINIQUE;SMITH CHRISTOPHER DENNIS;DI FLURI MARIA ROSARIA |
分类号 |
A61K31/4184;A61K31/435;A61K31/436;A61K31/444;A61K31/4545;A61K31/4709;A61K31/4725;A61K31/497;A61K31/498;A61K31/502;A61K31/506;A61K31/5377;A61P1/00;A61P3/10;A61P7/00;A61P9/00;A61P11/00;A61P11/02;A61P11/06;A61P13/08;A61P13/12;A61P15/00;A61P17/00;A61P17/06;A61P19/02;A61P21/00;A61P29/00;A61P31/18;A61P35/00;A61P37/02;A61P37/06;A61P37/08;A61P43/00;C07D235/10;C07D235/14;C07D401/12;C07D401/14;C07D403/12;C07D471/04;C07D471/06;C07D491/04;C07D491/052;(IPC1-7):C07D498/02;C07D471/02;C07D491/02;A61K31/470;A61K31/417 |
主分类号 |
A61K31/4184 |
代理机构 |
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地址 |
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