发明名称 |
Bifunctional chelating agent for the design and development of site specific radiopharmaceuticals and biomolecule conjugation strategy |
摘要 |
There is provided a method of labeling a biomolecule with a transition metal or radiometal in a site specific manner to produce a diagnostic or therapeutic pharmaceutical compound by synthesizing a P2N2-bifunctional chelating agent intermediate, complexing the intermediate with a radio metal or a transition metal, and covalently linking the resulting metal-complexed bifunctional chelating agent with a biomolecule in a site specific manner. Also provided is a method of synthesizing the -PR2 containing biomolecules by synthesizing a P2N2-bifunctional chelating agent intermediate, complexing the intermediate with a radiometal or a transition metal, and covalently linking the resulting radio metal-complexed bifunctional chelating agent with a biomolecule in a site specific manner. There is provided a therapeutic or diagnostic agent comprising a -PR2 containing biomolecule.
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申请公布号 |
US6635235(B1) |
申请公布日期 |
2003.10.21 |
申请号 |
US20000602487 |
申请日期 |
2000.06.23 |
申请人 |
THE CURATORS OF THE UNIVERSITY OF MISSOURI |
发明人 |
KATTI KATTESH V.;PRABHU KANDIKERE R.;GALI HARIPRASAD;PILLARSETTY NAGAVARA KISHORE;VOLKERT WYNN A. |
分类号 |
A61K49/00;A61K51/04;(IPC1-7):A61K51/00;A61M36/14 |
主分类号 |
A61K49/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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