发明名称 |
PHAGE DISPLAY AFFINITY AND SPECIFICITY FILTERS AND FORWARD SCREEN |
摘要 |
The invention provides an affinity filter for the binding of phage-displayed proteins to dissolved target molecules. The phage-displayed proteins are contacted with immobilized target in the presence and absence of dissolved target; the behavior of the phage-displayed proteins as a function of concentration of dissolved target permits approximation of the affinity of t he phage-displayed protein for target. The invention also provides a method to screen large numbers of compounds for their ability to complete with a compound known to bind a phage-displayed protein.
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申请公布号 |
CA2479177(A1) |
申请公布日期 |
2003.10.16 |
申请号 |
CA20032479177 |
申请日期 |
2003.04.02 |
申请人 |
AMBIT BIOSCIENCES CORPORATION |
发明人 |
TREIBER, DANIEL KELLY;ZARRINKAR, PATRICK P.;LOCKHART, DAVID J. |
分类号 |
C12N15/10;C40B40/02;(IPC1-7):C12Q1/70;C07H21/04;C12N15/00;C12P21/06;C12Q1/68;G01N33/53 |
主分类号 |
C12N15/10 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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