| 摘要 |
<p>A compound selected from those of formula (I): <CHEM> wherein: R1 represents cycloalkyl, heterocycloalkyl, aryl or heteroaryl group, which are optionally substituted as defined in the description, R2 represents alkyl, alkenyl, alkynyl, aryl or cycloalkyl group, R3 represents cycloalkyl, heterocycloalkyl, aryl or heteroaryl group, which are optionally substituted by halogen, nitro, cyano, trifluoromethyl, oxo, alkyl, OR6, NR6R7, COR6, CO2R6, CONHOH, CONR6R7, -S(O)mR6, -S(O)m-NR6R7, -NR6COR7, -NR6SO2R7, -N(SO2R7)2, -NR6-CO-NR7R8, and tetrazolyl, wherein m, R6, R7 and R8, are as defined in the description, and optionally, its optical isomers , N-oxide, and addition salts thereof with a pharmaceutically-acceptable acid or base, and medicinal products containing the same are useful as specific inhibitors of phosphosdiesterase-7 (PDE7).</p> |
