OPHTHALMIC COMPOSITION CONTAINING N-ACETYLCYSTEINE FOR THE TREAT MENT OF DRY-EYE SYNDROME
摘要
An ophthalmic pharmaceutical composition containing acetyl cysteine as the active ingredient having a mucolitic action, suitable for administration in eyedrops, where N-acetyl-cysteine is neutralised with base DEAE-dextrane in order to reach pH levels preferably between 6.0 and 7.5, and having a physiologically acceptable osmolarity less than 320 mOsm/kg. The presence of a neutralising agent for N-acetyl-cysteine that does not negatively affect the composition osmolarity allows the formulation to be isotonic or even hypotonic, thus avoiding the irritative and potentially damaging effects of previous ophthalmic products containing N-acetyl-cysteine
申请公布号
WO03011249(A3)
申请公布日期
2003.09.25
申请号
WO2002IT00481
申请日期
2002.07.22
申请人
FARMIGEA S.P.A.;BOLDRINI, ENRICO;SAETTONE, MARCO, FABRIZIO;CHETONI, PATRIZIA;BURGALASSI, SUSI;GIANNACCINI, BORIS
发明人
BOLDRINI, ENRICO;SAETTONE, MARCO, FABRIZIO;CHETONI, PATRIZIA;BURGALASSI, SUSI;GIANNACCINI, BORIS