TRANSMUCOSAL DELIVERY OF PROTON PUMP INHIBITORS

摘要

The present invention relates to pharmaceutical compositions and methods for transmucosaldelivery of proton pump inhibitors. In one embodiment, the pharmaceutical composition of thepresent invention comprises a core which comprises an antacid, and an outer layer surroundingthe core. The outer layer contains a therapeutically effective amount of a proton pump inhibitor.In another embodiment, the pharmaceutical composition of the present invention comprises an outer layer which comprising a unidirectional film, and an inner layer which contains a therapeutically effective amount of a proton pump inhibitor. In yet another embodiment, the pharmaceutical composition of the present invention is a unidirectional tablet for delivery of a proton pump inhibitor across the oral mucosa. In this embodiment, the pharmaceutical composition contains an outer layer which contains a pharmaceutically acceptable water impermeable layer, and an inner layer which contains a therapeutically effective amount of a proton pump inhibitor