发明名称 |
Isoform-selective inhibitors and activators of pde3 cyclic |
摘要 |
The present invention concerns methods and compositions related to type 3 phosphodiesterases (PDE3). Certain embodiments concern isolated peptides corresponding to various PDE3A isoforms and/or site-specific mutants of PDE3A isoforms, along with expression vectors encoding such isoforms or mutants. In specific embodiments, methods for identifying isoform-selective inhibitors or activators of PDE3 are provided, along with methods of use of such inhibitors or activators in the treatment of dilated cardiomyopathy, pulmonary hypertension and/or other medical conditions related to PDE3 effects on cAMP levels in different intracellular compartments. |
申请公布号 |
AU2002312543(A1) |
申请公布日期 |
2003.02.17 |
申请号 |
AU20020312543 |
申请日期 |
2002.06.19 |
申请人 |
UNIVERSITY OF UTAH, TECHNOLOGY TRANSFER OFFICE |
发明人 |
MATTHEW MOVSESIAN |
分类号 |
C12N15/09;A61K38/00;A61K45/00;A61K48/00;A61P7/02;A61P9/04;A61P9/06;A61P9/12;C12N9/16;C12N9/18;C12Q1/44 |
主分类号 |
C12N15/09 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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