发明名称 |
Opioid agonist /antagonist combinations |
摘要 |
The invention is directed in part to oral dosage forms comprising a combination of an orally analgesically effective amount of an opioid agonist and an orally active opioid antagonist, the opioid antagonist being included in a ratio to the opioid agonist to provide a combination product which is analgesically effective when the combination is administered orally, but which is aversive in a physically dependent subject. Preferably, the amount of opioid antagonist included in the combination product provides at least a mildly negative, "aversive" experience in physically dependent addicts (e.g., precipitated abstinence syndrome).
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申请公布号 |
US2003031712(A1) |
申请公布日期 |
2003.02.13 |
申请号 |
US20020244783 |
申请日期 |
2002.09.16 |
申请人 |
KAIKO ROBERT F.;COLUCCI ROBERT D. |
发明人 |
KAIKO ROBERT F.;COLUCCI ROBERT D. |
分类号 |
A61K45/06;A61K9/22;A61K31/135;A61K31/439;A61K31/451;A61K31/485;A61P25/04;A61P25/20;A61P25/36;A61P43/00;(IPC1-7):A61K31/485;A61K9/00 |
主分类号 |
A61K45/06 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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