MODULATION OF PHOSPHOINOSITIDE 3-KINASE ACTIVITY

摘要

The present invention discloses methods of modulating phosphoinositide 3-kinase (PI3K) activity or phosphatidylinositol-3,4,5-P3 (PIP3) production by targeting GTPase responsive domain or by expressing a p85 inhibitory domain of p85 subunit of phosphoinositide 3-kinase (PI3K) in cells. Methods for selecting modulators of PIP3 induction by small GTPases are also disclosed.